The ComBO project team aims to develop biomechanical models and numerical methods for analyzing and simulating human-system interaction in field, with a large application spectrum to sports, ergonomics and clinics. We define ourselves as digital biomechanicians, which is a unique skill within Inria, while having strong connections with the fields of robotics and virtual reality. ComBO is a joint project-team from Inria and the Universities of Rennes (including Université de Rennes, École normale supérieure de Rennes) and Rennes 2, studying human-system biomechanical interaction. The project-team integrates the eponymous team of the IRISA UMR6074 and relies on the eponymous team of the M2S EA7470 research unit.